October 16, 2021

Hüseyin Babal

Health Article

Diet that stops Alzheimer’s in mice

3 min read

A diet containing EGCG (epigallocatechin gallate) and FA (ferulic acid) has been used to treat Alzheimer’s symptoms in mice.

A diet consisting of certain ingredients found in green tea and carrots reversed Alzheimer’s-like symptoms in mice genetically programmed to develop Alzheimer’s. University of Southern California (USC) researchers state that this study was done in mice and that many discoveries made on mice could not be translated into human treatments. Still, the results suggest that some of the plant-based supplements currently in use are likely to protect against dementia in humans.

The researcher Prof. Terrence Town said, “You don’t have to wait 10-12 years for a special drug to hit the market. You can make these dietary changes even today. I think that’s very encouraging.” says.

Combination therapy worked

The study also supported the claim that a combination therapy could be more successful in the treatment of Alzheimer’s, rather than a single ‘magic’ drug. Combination therapy is currently used to treat diseases such as cancer, AIDS and rheumatism.

For this study, the researchers examined EGCG (epigallocatechin gallate) found in green tea and FA (ferulic acid) found in carrots, tomatoes, rice, wheat and oats. In the study, 32 mice with Alzheimer’s-like symptoms were divided into four equal groups. There were equal numbers of male and female mice in each group. An equal number of healthy mice were also added to each group for comparison purposes. For three months, mice were given a mixture of EGCG and FA, EGCG alone, FA only, or placebo only. The dosage was set at 30 milligrams per kilogram. This dosage can be easily consumed as part of the daily diet.

Test results

Before and after the three-month diet, the scientists subjected the mice to a neuropsychological test. These tests had more or less the same characteristics as the tests performed to detect dementia in humans. In one of the tests, mice were placed in a Y-shaped maze. This test examined the spatial working memory of the mouse. The same ability is used by humans for purposes such as finding the exit of a building.

Healthy mice instinctively navigate each branch of the Y-shaped maze one by one. Looking for a food or an outlet here. Sick mice, on the other hand, cannot perform this task as well as healthy ones.

After three months, the mice that received the combination therapy showed that their spatial working memory had completely recovered, and that the Alzheimer’s mice began to perform at the same level as the healthy mice.

Town says the ingredients used in the treatment prevent amyloid precursor proteins from breaking down and turning into small proteins called amyloid beta. These small proteins accumulate in the brains of Alzheimer’s patients and cause congestion. In addition, the components were observed to reduce neuroinflammation and oxidative stress in the brain. These conditions are known to be important causes of Alzheimer’s in humans.

Town stated that he and his lab will continue to explore the combination therapy, focusing on ingredients derived from plants.

Source: University of Southern California

A diet consisting of certain ingredients found in green tea and carrots reversed Alzheimer’s-like symptoms in mice genetically programmed to develop Alzheimer’s. University of Southern California (USC) researchers state that this study was done in mice and that many discoveries made on mice could not be translated into human treatments. Still, the results suggest that some of the plant-based supplements currently used are likely to protect against dementia in humans. The researcher Prof. Terrence Town “You don’t have to wait 10-12 years for a specific drug to hit the market. You can still make these dietary changes today. I think that’s very encouraging.” says.

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