October 16, 2021

Hüseyin Babal

Health Article

Doctors tried drugs on fish to find a cure for the sick child

3 min read

The genetic disease of a child hospitalized at Philadelphia Children’s Hospital was treated by applying zebrafish to it.

A zebrafish saved the life of a boy named Daniel, who was born with a rare, complex genetic disease. When he was brought to the hospital, the boy, whose legs and stomach were swollen, had to use an oxygen tank as his lungs were constantly filled with fluid.

As a result of their investigations, Doctor Hakon Hakonarson and his colleagues, who figured out that the child’s disease was caused by a genetic mutation, applied the same mutation to the zebrafish. They then waited for the disease to appear in the fish. After trying various drugs on the fish, they found that one of them was successful in stopping the disease. The researchers said that they did not have to give the drug to the animal with a needle as in the mice, and when they dropped the drug into the water, the fish swallowed the drug. Doctors administered the drug to the young patient, with permission from federal health officials. The drug that was successful in stopping the disease was Novartis’ drug called Mekinist.

One out of every 4,000 newborns has lymphoma.

Monday Nature Medicine The treatment worked, according to the report published in the magazine. Other researchers who were not involved in Daniel’s treatment say Daniel’s condition is interesting in approaching lymphoma diseases with genetic techniques. Because 1 out of every 4,000 newborns is diagnosed with lymphoma. “With this approach, we can run genetic trials to find out where the problem is in the patient’s body, and then try to find drugs that can solve the problem,” says Doctor V. Reid Sutton, who works at Texas Children’s Hospital, where 50 children with lymphoma are treated each year. says.

The patient returned to his daily life

Within two months of being given the medication, Daniel’s breathing improved. Within three months, the fluid in his lungs was withdrawn spontaneously, without the need to use an oxygen tank. The swelling in his legs has gone. The MRI showed that the lymph vessels had turned into a near-normal shape. Thus, it was the first time that a drug changed the shape of an entire organ system. Daniel, now 14 years old, can play basketball and ride a bike.

Source: Stat News

A zebrafish saved the life of a boy named Daniel, who was born with a rare, complex genetic disease. As a result of research, Doctor Hakon Hakonarson and his colleagues, who figured out that the child’s disease was caused by a genetic mutation, applied the same mutation to the zebrafish. They then waited for the disease to appear in the fish. After trying various drugs on the fish, they found that one of them was successful in stopping the disease. The researchers said that they did not have to give the drug to the animal with a needle as in the mice, and when they dropped the drug into the water, the fish swallowed the drug. The doctors, after obtaining permission from the authorities, gave the drug to the young patient. The treatment’s work was announced in an article published in the journal Nature Medicine. The drug that was successful in stopping the disease was Novartis’ drug called Mekinist.

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