October 16, 2021

Hüseyin Babal

Health Article

Liver transplant with newly discovered cell may become a thing of the past

2 min read

Researchers at King’s College London have discovered a new type of cell. This development could put liver transplantation on the shelf.

Recently Nature Communications In an article published in the journal , it was mentioned that a new type of cell called hepatobiliary hybrid progenitor (HHyP) was discovered during the mother’s womb. HHyP cells, which are found in small amounts in adults, can transform into the two basic cell types (hepatocytes and cholangiocytes) found in our livers. This gives HHyP cells stem cell-like properties.

Examining these cells, the research team found that HHyP cells were similar to mouse stem cells, which they noticed quickly repaired the liver of mice after major damage (such as cirrhosis).

“We noticed for the first time that cells with stem cell-like properties can also be found in the human liver,” said Dr Tamir Rashid, lead researcher at the Center for Stem Cell and Regenerative Medicine. This development holds promise for treating liver disease by shelving the option of organ transplant.” says.

Liver disease ranks fifth in the list of causes of death.

Liver disease is the fifth leading cause of death in the UK. Also, the third most common cause of premature death is liver disease. This disease can be caused by causes that are not related to lifestyle, such as obesity, viruses, excessive alcohol consumption, or autoimmune and genetic disease. Symptoms of liver disease include unhappiness, itching, feelings of weakness and fatigue. In more severe cases, cirrhosis is seen. Currently, the only solution to severe liver diseases is liver transplantation, which can cause lifelong complications. Dr. Rashid said, “What we need to do now is to find a way to transform the pluripotent stem cells into HHyP cells. Thus, these cells can be transplanted into the patient’s body at any time.” says.

Source: KCL

In an article published in the journal Nature Communications recently, it was mentioned that a new type of cell called hepatobiliary hybrid progenitor (HHyP) was discovered during the mother’s womb. HHyP cells, which are found in small amounts in adults, can differentiate into the two basic cell types (hepatocytes and cholangiocytes) found in our livers. This gives HHyP cells stem cell-like properties. Thanks to this development, Doctor Tamir Rashid, who works at the Center for Stem Cell and Regenerative Medicine, says that they can completely shelve the option of liver transplant, which has the potential to create lifelong complications.

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